Oral gavage, also known as oral dosing, is a method of administering drugs or other substances to animals, typically rodents such as mice or rats, by delivering the substance directly into the stomach through a tube that is inserted into the animal’s mouth.

The oral gavage technique involves restraining the animal, placing a gavage needle or tube into the animal’s mouth, and guiding it down the esophagus and into the stomach. The substance to be administered, such as a drug or nutrient solution, is then delivered through the tube into the stomach.

Oral gavage is a commonly used method in preclinical research for testing the effects of drugs or other substances on animals. However, it is important to note that the procedure can be stressful for the animal and can potentially cause injury or discomfort if not performed carefully and skillfully.

Alternatives to oral gavage, such as oral administration via food or water or subcutaneous injections, may be considered depending on the specific research question and animal model being used. It is important for researchers to carefully consider the potential effects of any experimental procedures on the well-being of the animals involved and to take steps to minimize pain and distress.